Mostly posting this so I can talk about the one hardship i currently experience with my human colonies on any world.
Education.
Since education became important, I have noticed a steady increase of protesters in colonies that previously had none. After some digging, I found out why.
In every case, i had just recently built up a bunch of research labs or one of the various stages of school buildings, and even after leaving the population be for several hours, those buildings (all of which require certain IQ levels) are still missing most if not all of their employees. Without realizing this at first I had waited until the population matched the jobs available and then expanded further so I can control who lives where and reduce commute times and fatigue.
Well, since the colonists were either too lazy to get their IQ up, or it seems to take an ungodly amount of time for it to get up, I have a pile of unemployed colonists who leap into working at that new microchip factory I just built 35 blocks away from their home instead of the lab/school that is literally 1 block away. Since this discovery I have just been more careful to let people get learned (Or die off and be replaced because they protest and refuse to see the many available doctors to heal and live) before I build anything after adding new IQ required buildings.