I played this game before regions were introduced and i get into late game several times. There was a point where performance started to fall down and it was unplayeable. Now, with the region setting, i know that that wouldn´t happen, but if i wan to have homes in one region, i must also put the colonist producers there, food producers, water... in the same region in order for them to not die, so i dont know what of both options its better for going late game and staying full nights AFK